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Considering “The Immortalists”

24 Jul

I’ve been wanting to see the 2014 documentary “The Immortalists” since it was released, so when it appeared on Netflix this month, I streamed it immediately. Here’s the trailer if you haven’t seen the film:

The documentary is mostly focused on Bill Andrews and Aubrey de Grey, evangelical researchers fighting to “cure aging”.  They’re interesting fellows and the filmmakers are rather sly in how they cut together their personal and professional stories. You can watch simply to see two passionate people pursuing a cause in which they fervently believe, or go deeper into the scientific and ethical issues that are hinted at throughout the narrative.

Some spoilers for the film are below, so stop here if you want to see the story unfold on your own.

I was struck by several things as I watched. First, that neither man has done the basic act many people do to ensure that some part of themselves lives on: reproduce. De Grey married a scientist in her mid-40s when he was younger and there was no mention of children with the two girlfriends revealed near the end of the film. Andrews mentioned several failed engagements in his 20s, and when he found a partner, she was past reproductive age. Though the men talk about future generations, it’s somewhat surprising that neither will have descendants of their own among them.

The two men have different approaches to the problem of aging. Andrews points to the fact that our telomeres behave like the tick of a clock counting down: each time a cell divides, the telomeres become shorter.  Therefore he sees the key problem as one of resetting the clock by extending telomere length. De Grey, on the other hand, is concerned with waste material that builds up inside cells over time, attributing diseases of aging and perhaps aging itself to the toxic effects of waste that normal processes were unable to clean. The enzymes to break down that material exist, he insists, explaining that no accumulation of those toxins can be found in graveyard dirt.

After reading that, if I told you that one man had a hoarding mother whose home had to be emptied of tons of trash when she died, and the other runs ultramarathons of incredible duration, could you tell me which was which? Of course you could. The filmmakers don’t rub your nose in parallels like those, but they provide the material for you to find them.

As much as I admire de Grey for shamelessly wearing scrunchie ponytails in public (I wish I was so brave), he sometimes seems overly aware of his brand image and perhaps he’s read a bit too much Heinlein. Andrews seems earnest but grasping, lacking the hippie chic of his polyamorous, heavy-drinking counterpart and desperate to be taken seriously before time runs out.

The parts of the film devoted to questioning the science or ethics of either approach are small but significant. Andrews comes under attack by the scientist who discovered that there is a limit to human cell divisions. De Grey engages in a debate with someone who argues that humanity is responsible for too many problems on this planet as it is, and that overpopulation, global warming, and other problems need to be addressed before we greatly extend human life.  I thought his response to that — that other scientists are working in parallel on other problems and that we do not have good predictions about where things will be in 100 years — was quite good, but I also, like his opponent, fear a sudden breakthrough in life extension.

Personally, I think that life extension research is vital for space exploration and colonization that I feel must be part of our future. I think it poses ethical problems here on Earth, where money and access to Western medicine would decide which populations would first have radically lengthened lives. I think of de Grey’s comment about his mother, shown in the trailer above, where he says she certainly hadn’t done everything she wanted to do in her life. I’m sure that will be true for me, too, but the limiting factor is money more than time. Should a person have to prove that she could support herself for additional decades of life before being given a therapy to provide them?  If not, how will society, economic systems, and family structure have to change to accommodate a new group of super-seniors?  Will super-seniors of limited means be forced to work menial jobs and submit to strict lifestyle restrictions to earn support from society? (Not a crazy suggestion: in some parts of the US, people who receive support money from the government have limits on how it can be spent, may have to work a low-level job unless they are medically unable, may have to submit to drug tests, and may only be able to live in some areas, among other constraints.)

I’m also basically skeptical of preserving our organic selves. Our bodies and brains are wondrous things, but they’re so complicated and flawed. Though I often think Ray Kurzweil is nuttier than a fruitcake, the idea of being able to upload enough of my consciousness to be “me” is more appealing than trying to repair this bag of meat for eternity. Perhaps we’ll discover, definitively, that consciousness cannot exist without a significant amount of human flesh. If it can, however, sign me up for a simplified digital and robotic casing that can be upgraded to whatever comes next. Writing from my wheelchair, I’m not so impressed by my current organic packaging, but the metal bits seem to work just fine.

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3 Comments

Posted by on July 24, 2015 in Health - Mental & Physical, Transhumanism

 

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3 responses to “Considering “The Immortalists”

  1. girlforgetful

    July 24, 2015 at 5:17 pm

    Hmmm. I rather prefer the idea of reincarnation; starting over with a new body and having no memory of the past. I don’t see a benefit to society to extend physical life, with the possible exception of some geniuses working to find solutions to the world’s problems that threaten all life, who need just a little more time to get the results.

     
  2. Johnty Andersen

    July 25, 2015 at 5:01 pm

    It’s interesting how fast things are moving in this field. When I first saw the trailer for The Immortalists last year I was quite sceptical regarding Dr Bill Andrews because there were numerous issues concerning telomere lengthening which raised concerns as I will outline in the next paragraph and whilst my money would still be on SENS the research involving telomeres at Stanford University in the United States has massively changed the position regarding our knowledge of areas such as cell division.

    Just to summarize I have to say that I’m of the opinion that the current breakthroughs in the area of telomere research relating to the lengthening of telomeres is of extreme interest to me at the moment because the research is moving extremely fast and clearly it is technically possible and highly probable it will translate into humans. The primary concern with the lengthening of telomeres used to lie in the theoretically elevated risk of cancer but this problem does not apply based on the current research which you can see on the Stanford University website at this URL – https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html – as a researcher in aging I consider this research and some supporting and complimentary research which has taken place at Harvard coupled with additional research relating to a compounds that is related to Rapamycin tends to indicate that we are finally making significant progress in addressing the diseases of aging. Interestingly shortening of telomeres was until recently perceived by many as being a result of aging and not causal but the research at Stanford clearly repudiates this and suggests that Dr Bill Andrews was correct all the way along so I am reading the research of Dr Bill Andrews and treating it with the greatest of respect.

    There are already products on the market which claim that they can provide “healthy Telomere support” a typical example is this one here Product B – Telomeres and Aging – Isagenix.com I’m uncertain as to the benefits of these products but I know that the future potential is enormous and product B is particular interest to me because it is supported by Dr Bill Andrews himself who is a leading authority on telomeres and his website is here Sierra Sciences/Staff

    As far as the mechanism of delivery which has been developed so far the scientists at Stamford used modified messenger RNA to extend the telomeres so the whole process if it translates effectively into humans – and the evidence is suggesting it will – would be pretty straightforward especially when you consider the degree of extension which is 1000 nucleotides and the fact that the telomerase which lengthens the telomeres is only active in the body for 48 hours which means there is no significant risk of cancer due to the limited time during which proliferation of the cells could take place.

     
    • Kay

      July 25, 2015 at 7:55 pm

      Thank you for the thoughtful and informative comment!

       

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